Betaine (trimethylglycine) is a key human nutrient present in most tissues and is endogenously synthesized from choline in the liver and kidney. Betaine plays several important biological roles including its role as an osmoprotectant, methyl group donor, reducing plasma homocysteine levels and improving inflammation and oxidative stress. Emerging evidence suggests its potential therapeutic application for alleviating fat accumulation in the liver and the associated liver injury.

Hypochlorhydria is common in several medical conditions including Helicobacter pylori infection and prevalent in geriatric population suffering from atrophic gastritis. Hypochlorhydria can also result due to repeated usage of acid-reducing pharmacological agents. A hydrochloric acid (HCl) supplement such as betaine HCl is very useful in this scenario, where free HCl is produced by dissociation once it reaches the stomach. HCl-Pepsin SAP delivers an optimal combination of betaine HCl and pepsin that can help support digestion and improve liver function.