Since I'm just beginning to use Mitochondrial NRG, it's hard to know, besides I've completely forgot to take it this morning. Also, since we need to take it with food, I only have a breakfast and a dinner later in at night, so if take it at night, I won't sleep very well because of too much energy. Often what I do, I take the 4 pills at my breakfast. I'm suffering from a neurological disease called "Myalgic Encephalomyetis" since after I took the H1N1 vaccine in December 2009. This is a Syndrrome so there are multiple symptoms. Researchers at Harvard, Harford, Montreal and other important universities throughout the world are working hard to find a remedy. So, since 2011, I don't have a life, I'm surviving now the help of Amphetamins, otherwise I would spend a lot of time in bed. You can ask me again in 3 weeks may be and I'll be more happy to give you a more precise result. I just hope that it will work and then I could cut amphetamins.