AMPK is a master control mechanism for cellular energy homeostasis. It determines body fat composition and has a significant impact on mitochondrial biogenesis, the diabesity spectrum and life span extension in mice models. considerations: hyperadrenia, hypoadrenia, stress, hyperinsulinism, afternoon tiredness, and depression. The adrenals may have many hormone connections. The Adrenals and the hormone cortisol can influence thyroid function, blood sugar levels, hypertension, sleep patterns and weight loss. Always address the thyroid function when assessing adrenal function. Stressed Adrenal clients may suffer from hot flashes and diminished sex drive.