Spotlight on Metagenics SPM Active
Reviewed byAs we age, staying active and comfortable in our bodies becomes increasingly important. Simple activities like gardening, walking the dog, or playing with grandchildren can sometimes leave us feeling sore the next day. Chronic low-level inflammation can also sneak in over time, making recovery slower and affecting mobility.
That’s where Metagenics SPM Active comes in - a supplement designed to help the body naturally resolve inflammation and support tissue health, mobility, and comfort.

What Are Specialized Pro-Resolving Mediators (SPMs)?
Most people are familiar with omega-3 fatty acids in fish oil and how they can support heart and joint health. But did you know that the body actually converts some of these omega-3s into Specialized Pro-Resolving Mediators (SPMs)?
SPMs are like the body’s natural “off-switch” for inflammation. Instead of just blocking inflammation, they help resolve it, guiding tissues back to balance after stress, injury, or daily wear and tear.
SPM Active delivers these mediators directly, so your body doesn’t have to rely solely on conversion from regular fish oils. This targeted approach is especially beneficial for adults and older adults, whose natural production of SPMs may decline with age.
How SPM Active Supports Adults and Older Adults
1. Joint Comfort and Mobility
Everyday movements like climbing stairs, walking, or lifting groceries can sometimes trigger mild inflammation, leading to stiffness or discomfort. By helping resolve inflammation at the tissue level, SPM Active supports joint comfort and fluid movement, making it easier to stay active.
2. Muscle Recovery and Physical Activity
For those who stay active, SPM Active may help reduce post-activity soreness, allowing you to recover faster. Whether it’s a brisk walk, yoga class, or light resistance training, supporting your body’s recovery process helps maintain long-term mobility.
3. Tissue Health and Resilience
As we age, tissues take longer to repair. Supporting the natural resolution of inflammation helps maintain healthy tissue function, which can benefit overall comfort, flexibility, and long-term joint and muscle health.
4. Proactive Healthy Aging
SPM Active isn’t just about reacting to discomfort - it’s about preventing chronic low-grade inflammation and supporting healthy aging. Maintaining tissue balance and reducing unnecessary stress on joints and muscles can help you stay independent, active, and comfortable for years to come.
The Science Behind SPM Active
Metagenics SPM Active is made from marine lipids derived from anchovies, sardines, and mackerel and standardized to provide active SPMs, including:
-
18‑hydroxy‑eicosapentaenoic acid (18‑HEPE)
-
17‑hydroxy‑docosahexaenoic acid (17‑HDHA)
-
14‑hydroxy‑docosahexaenoic acid (14‑HDHA)
Clinical studies show that adults taking SPM Active reported reduced soreness and improved joint comfort in as little as two weeks. Unlike standard fish oils, which rely on the body to convert omega-3s into SPMs (a process that becomes less efficient with age), SPM Active delivers the mediators directly, providing a more targeted approach.
How to Take SPM Active
- SPM Active: 2 softgels per day
- Take with meals containing healthy fats for better absorption
- Consistent daily use is recommended as effects may take a few weeks to notice
How SPM Active Compares to Other Options
|
Feature |
SPM Active |
Standard Fish Oil |
NSAIDs / Pain Relievers |
|
Mechanism |
Delivers mediators that resolve inflammation |
Provides omega-3s as precursors to SPMs |
Blocks inflammation enzymes (COX) |
|
Speed of relief |
Noticeable in ~2 weeks |
Slower; depends on conversion efficiency |
Fast relief (hours to days) |
|
Long-term impact |
Supports healthy tissue function |
Beneficial, but conversion may be less efficient |
May have side effects with chronic use |
|
Safety |
Fish allergy; high-quality lipids |
Fish allergy; oxidative risk with high doses |
Gastrointestinal, kidney, cardiovascular risks with long-term use |
Lifestyle Tips to Maximize Benefits
SPM Active works best as part of a holistic approach to healthy aging:
- Stay Active: Gentle resistance training, walking, yoga, or swimming keeps joints flexible and muscles strong.
- Eat Anti-Inflammatory Foods: Colorful vegetables, fruits, healthy fats, and lean proteins support tissue health.
- Prioritize Sleep: Quality rest allows your body to repair and resolve inflammation naturally.
- Hydrate Well: Water supports joint lubrication and overall cellular health.
- Consistency Is Key: Supplements like SPM Active are most effective when taken daily and combined with healthy lifestyle habits.
Aging doesn’t mean giving up comfort or mobility. SPM Active offers a science-backed, targeted approach to support the body’s natural ability to resolve inflammation, recover from activity, and maintain healthy joints and tissues. For adults and older adults, this means less soreness, faster recovery, and more freedom to stay active and independent.
Disclaimer: The information provided in this blog is for educational purposes only and should not be considered as a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider regarding any medical condition, dietary changes, or supplementation.